Domstal 10mg (domperidone) works primarily by blocking dopamine receptors in the brain and gastrointestinal (GI) tract. Its mechanism of action involves the following:
Dopamine Antagonism: Domperidone acts as a dopamine antagonist, specifically targeting dopamine D2 receptors. Dopamine is a neurotransmitter that plays a role in regulating various processes, including gastrointestinal motility. By blocking these receptors, domperidone inhibits the inhibitory effect of dopamine on the GI tract, leading to increased gut motility.
Enhanced Gastric Emptying: Domperidone promotes the movement of food through the stomach and intestines. It stimulates the contraction of the muscles in the GI tract, particularly the muscles of the stomach and upper intestine. This enhances gastric emptying, allowing food to pass through the digestive system at a normal rate.
Antiemetic Effect: Domperidone has antiemetic properties, meaning it can help alleviate nausea and vomiting. By blocking dopamine receptors in the brain's chemoreceptor trigger zone (CTZ), which is responsible for triggering the vomiting reflex, it reduces the sensation of nausea and helps to suppress vomiting.
By increasing gastrointestinal motility and reducing nausea and vomiting, Domstal 10mg can provide relief from symptoms associated with various conditions, including gastroesophageal reflux disease (GERD), gastroparesis, functional dyspepsia, and other gastrointestinal disorders.
It's important to note that Domstal 10mg acts primarily on the gastrointestinal system and does not cross the blood-brain barrier to a significant extent, which reduces the likelihood of central nervous system side effects associated with other dopamine antagonists.